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Desmin Antibody

Purified Mouse Monoclonal Antibody

  • WB - Desmin Antibody AO1075a
    Figure 1: Western blot analysis using Desmin mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY Desmin cDNA (2).
  • IHC - Desmin Antibody AO1075a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human smooth musde sarcoma, showing cytoplasmic localization using Desmin mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17661
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 10H7D2
Isotype IgG1
Calculated MW 53536 Da
Description Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.
Immunogen Purified recombinant fragment of Desmin expressed in E. Coli.
Formulation Purified antibody in PBS containing 0.03% sodium azide.
Additional Information
Gene ID 1674
Other Names Desmin, DES
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDesmin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DES
Function Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Cellular Location Cytoplasm. Cell membrane, sarcolemma
Research Areas
Citations (0)

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1. Felix R. Shardonofsky, Yassemi Capetanaki, and Aladin M. Boriek. Am J Physiol Lung Cell Mol Physiol, May 2006; 290: L890 - L896. 2. Xupei Huang, Jian Li, Dalton Foster. Experimental Biology and Medicine, Dec 2002; 227: 1039.

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$ 300.00
Cat# AO1075a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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