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PR Antibody

Purified Mouse Monoclonal Antibody

  • WB - PR Antibody AO1085a
    Figure 1: Western blot analysis using PR mouse mAb against PR recombinant protein (1).
  • IHC - PR Antibody AO1085a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human infiltrating ductal carcinoma tissue(left) and simple carcinoma of breast cancer tissue(right), showing nuclear localization using PR mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06401
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2F12B4; 2F12H2
Isotype IgG1
Calculated MW 98981 Da
Description PR(progesterone receptor), with 933-amino acid protein (about 110kDa), a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone, PR is mediated by two functionally different isoforms of the progesterone receptor, the full length PR-B and the short form PR-A. The PR-A and PR-B proteins are 94 kDa and 114 kDa respectively. That are equimolar in the normal breast but dysregulated in advanced disease. PR is prognostic markers in breast cancers irrespective of the patient's progestational status Human progesterone.
Immunogen Purified recombinant fragment of PR expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 5241
Other Names Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PGR
Synonyms NR3C3
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Cellular Location Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases Isoform 4: Mitochondrion outer membrane
Research Areas
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1. McGuire, W.L., et al. 1986. Cancer.Surv.5:527-536. 2. Helena CD, Curt WB, Paul V,et al. 2000. J.Clin. Pathol. 53:201-205. 3. Wen, D.X., et al. 1994.Mol.Cell.Biol.14:8356-8364. 4. GM Clark, CK Osborne, WL McGuire.1984.J. Clin. Oncol., 2:1102-1109.

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$ 300.00
Cat# AO1085a
(40 western blots)
Availability: 7-10 days
Bulk Size
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