S100A1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC, E |
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Primary Accession | P23297 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2C8B8; 2C8E8; 3C8D8 |
Isotype | IgG1 |
Calculated MW | 10546 Da |
Description | S100 calcium binding protein A1 (S100-alpha/ S100A1), it is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. |
Immunogen | Purified recombinant fragment of S100A1 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Gene ID | 6271 |
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Other Names | Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100A1, S100A |
Dilution | WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | S100A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | S100A1 |
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Synonyms | S100A |
Function | Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. |
Cellular Location | Cytoplasm. |
Tissue Location | Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain |

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Provided below are standard protocols that you may find useful for product applications.
References
1. Koenig A, Wojcieszyn J, Weeks BR, et al. Vet Pathol. 2001;38(4):427-35. 2. Hoyaux D, Decaestecker C, Heizmann CW, et al. Brain Res. 2000;867(1-2):280-8. 3. Pingerelli PL, Mizukami H, Wagner AS, et al. J Protein Chem. 1990;9(2):169-75.

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