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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AMACR Antibody   

AMACR Antibody

Purified Mouse Monoclonal Antibody

  • WB - AMACR Antibody AO1128a
    Figure 1: Western blot analysis using AMACR mouse mAb against Jurkat (1) and LNCaP (2) cell lysate.
  • IHC - AMACR Antibody AO1128a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human normal prostate tissues (left) and prostate adenocarcinoma tissues (right), showing cytoplasmic localization using AMACR mouse mAb with DAB staining.
  • IHC - AMACR Antibody AO1128a
    Figure 3: Immunohistochemical analysis of paraffin-embedded human brain cerebellum using AMACR mouse mAb.
  • IF - AMACR Antibody AO1128a
    Figure 4: Confocal immunofluorescence analysis of LNCaP cells using AMACR mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UHK6
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 2A10F3
Isotype IgG2b
Calculated MW 42kDa
Description AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. AMACR can be used as a positive marker for PIN. Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4); also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.
Immunogen Purified recombinant fragment of human AMACR expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 23600
Other Names Alpha-methylacyl-CoA racemase,, 2-methylacyl-CoA racemase, AMACR
Dilution WB~~1/500 - 1/2000
IHC~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAMACR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
Cellular Location Peroxisome. Mitochondrion
Research Areas
Citations (0)

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1. Chen Q. Watson JT. Marengo SR. et al. Cancer Lett. 2006, Dec 8, 244 (2):274-88.Epub 2006 Feb 23. 2. Epstein JI. Herawi M. J Urol. 2006, Mar, 175 (3 Pt 1):820-34. Review.

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$ 385.00
Cat# AO1128a
(40 western blots)
Availability: 7-10 days
Bulk Size
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