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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IFN-gamma Antibody   

IFN-gamma Antibody

Purified Mouse Monoclonal Antibody

  • WB - IFN-gamma Antibody AO1133a
    Figure 1: Western blot analysis using IFN-gamma mouse mAb against IFN-gamma recombinant protein.
  • IHC - IFN-gamma Antibody AO1133a
    Figure 1: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using CD20 mouse mAb.
  • IF - IFN-gamma Antibody AO1133a
    Figure 1: Immunofluorescence analysis of B lymphocytes using anti-CD20 antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01579
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B1A4; E8H1
Isotype IgG1
Calculated MW 19348 Da
Description IFN-gamma (interferon, gamma) is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natural killer cells that undergo activation by antigens, mitogens or alloantigens. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. The active form of IFN-G is a homodimer with each subunit containing six helices. The dimeric structure of human IFN-G is stabilized by non-covalent interactions through the interface of the helices. IFN-G translated precursor is 166 amino acids, including the 23 amino acid secretory sequence. It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Multiple forms exist due to variable glycosylation and under non-denaturing conditions due to dimers and tetramers.
Immunogen Recombinant human IFN-gamma (BioSource company, Cat.No. PHC4033)
Formulation Purified antibody in PBS containing 0.03% sodium azide.
Additional Information
Gene ID 3458
Other Names Interferon gamma, IFN-gamma, Immune interferon, IFNG
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIFN-gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Cellular Location Secreted.
Tissue Location Released primarily from activated T lymphocytes
Research Areas
Citations (0)

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1. Dean GA. LaVoy A. Burkhard MJ. Vet Immunol Immunopathol. 2004,Jul, 100(1-2):49-59. 2. Arens R. Schepers K. Nolte MA. et al. J Exp Med. 2004,Jun 7, 199(11):1595-605. 3. Podhorecka M. Dmoszynska A. Rolinski J. Eur J Haematol. 2004,Jul, 73(1):29-35.

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$ 325.00
Cat# AO1133a
(40 western blots)
Availability: 7-10 days
Bulk Size
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