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EhpB6 Antibody

Purified Mouse Monoclonal Antibody

  • WB - EhpB6 Antibody AO1153a
    Figure 1: Western blot analysis using EhpB6 mouse mAb against truncated EhpB6 recombinant protein (1).
  • IHC - EhpB6 Antibody AO1153a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human lymph node (left) and brain (right), showing cytoplasmic localization with DAB staining using EhpB6 mouse mAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15197
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2A6B9
Isotype IgG1
Calculated MW 110700 Da
Description EhpB6: EPH receptor B6. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.
Immunogen Purified recombinant fragment of EphB6 (aa601-750) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 2051
Other Names Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6, EPHB6
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEhpB6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPHB6
Function Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
Research Areas
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1. J Clin Invest. 2002 Oct;110(8):1141-50. 2. J Biol Chem. 2002 Feb 8;277(6):3823-8. Epub 2001 Nov 16. 3. J Biol Chem. 2003 Mar 21;278(12):10150-6. Epub 2003 Jan 6. 4. Biochem Biophys Res Commun. 2006 Feb 3;340(1):268-76.

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$ 325.00
Cat# AO1153a
(40 western blots)
Availability: 7-10 days
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