|Application ||WB, E|
|Clone Names||7H4F6; 3B9A11|
|Calculated MW||126573 Da|
|Description||FBLN2: fibulin 2. This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified.|
|Immunogen||Purified recombinant fragment of FBLN2 (aa180-440) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Fibulin-2, FIBL-2, FBLN2|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBLN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary|
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1. J Biol Chem. 1996 Aug 9;271(32):19489-96. 2. Eur J Hum Genet. 1996;4(5):292-5. 3. J Invest Dermatol. 1999 Jan;112(1):97-101. 4. Br J Dermatol. 2001 Aug;145(2):217-22.
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