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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FBLN5 Antibody   

FBLN5 Antibody

Purified Mouse Monoclonal Antibody

  • WB - FBLN5 Antibody AO1164a
    Figure 1: Western blot analysis using FBLN5 mouse mAb against truncated FBLN5-His recombinant protein.
  • IHC - FBLN5 Antibody AO1164a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human colon cancer (left) and breast cancer (right) showing cytoplasmic localization with DAB staining using FBLN5 mouse mAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBX5
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1G6A4
Isotype IgG1
Calculated MW 50180 Da
Description FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.
Immunogen Purified recombinant fragment of FBLN5 (aa242-448) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 10516
Other Names Fibulin-5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50, FBLN5, DANCE
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBLN5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBLN5
Synonyms DANCE
Function Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823).
Cellular Location Secreted Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.
Tissue Location Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).
Research Areas
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1. Am J Hum Genet. 2003 Apr;72(4):998-1004. 2. Genome Res. 2003 Oct;13(10):2265-70 3. N Engl J Med. 2004 Jul 22;351(4):346-53. 4. Surgery. 2005 Aug;138(2):352-9.

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$ 385.00
Cat# AO1164a
(40 western blots)
Availability: 7-10 days
Bulk Size
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