|Application ||WB, E|
|Calculated MW||65102 Da|
|Description||ALCAM(CD166): Activated leukocyte cell adhesion molecule.CD166 is a member of the Ig superfamily and is expressed on activated T-cells, B cells and other cells including thymic epithelial cells, fibroblasts, keratinocytes and neurons. CD6 has been identified as a receptor for CD166.|
|Immunogen||Purified recombinant fragment of ALCAM (aa405-524) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||CD166 antigen, Activated leukocyte cell adhesion molecule, CD166, ALCAM, MEMD|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.|
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