GABPA Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, ICC, E |
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Primary Accession | Q06546 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 8C1B10 |
Isotype | IgG1 |
Calculated MW | 51kDa |
Description | GABPA: GA binding protein transcription factor, alpha subunit 60kDa. It is one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, it may play a role in the Down Syndrome phenotype. |
Immunogen | Purified recombinant fragment of human GABPA (aa120-190) expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Gene ID | 2551 |
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Other Names | GA-binding protein alpha chain, GABP subunit alpha, Nuclear respiratory factor 2 subunit alpha, Transcription factor E4TF1-60, GABPA, E4TF1A |
Dilution | WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GABPA Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GABPA |
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Synonyms | E4TF1A |
Function | Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Science. 1998 Feb 13;279(5353):1037-41. 2. J Biol Chem. 1999 Dec 10;274(50):35475-82. 3. EMBO J. 2000 Feb 15;19(4):683-90.
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