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PARL Antibody

Purified Mouse Monoclonal Antibody

  • WB - PARL Antibody AO1197a
    Figure 1: Western blot analysis using PARL mouse mAb against truncated Trx-PARL recombinant protein (1) and truncated MBP-PARL(aa112-167) recombinant protein (2).
  • IHC - PARL Antibody AO1197a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebra (left) and lung carcinoma (right) tissues, showing nuclear localization with DAB staining using MDM4 mouse mAb.
  • IF - PARL Antibody AO1197a
    Figure 3: Confocal immunofluorescence analysis of Hela (left) and L-02 (right) cells using anti-MDM4 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H300
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8C4B2; 1H12E10
Isotype IgG2b
Calculated MW 42190 Da
Description PARL: presenilin associated, rhomboid-like. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 55486
Other Names Presenilins-associated rhomboid-like protein, mitochondrial,, Mitochondrial intramembrane cleaving protease PARL, P-beta, Pbeta, PARL, PSARL
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPARL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PSARL
Function Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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1. J Alzheimers Dis. 2001 Apr;3(2):181-190. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Nature. 2003 May 29;423(6939):537-41.

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$ 300.00
Cat# AO1197a
(40 western blots)
Availability: 7-10 days
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