|Application ||WB, E|
|Clone Names||8C4B2; 1H12E10|
|Calculated MW||42190 Da|
|Description||PARL: presenilin associated, rhomboid-like. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.|
|Immunogen||Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide. |
|Other Names||Presenilins-associated rhomboid-like protein, mitochondrial, 22.214.171.124, Mitochondrial intramembrane cleaving protease PARL, P-beta, Pbeta, PARL, PSARL|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PARL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
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1. J Alzheimers Dis. 2001 Apr;3(2):181-190. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Nature. 2003 May 29;423(6939):537-41.
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