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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NCOR1 Antibody   

NCOR1 Antibody

Purified Mouse Monoclonal Antibody

  • WB - NCOR1 Antibody AO1216a
    Figure 1: Western blot analysis using NCOR1 mouse mAb against truncated Trx-NCOR1 recombinant protein (1).
  • IHC - NCOR1 Antibody AO1216a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebra (left) and breast carcinoma tissue (right), showing nuclear location with DAB staining using NCOR1 mouse mAb.
  • ICC - NCOR1 Antibody AO1216a
    Figure 2: Confocal immunofluorescence analysis of methanol fixed Hela cells were transfected with pMX construct of human LIN28, cells were analyzed ~62 hours after transfection.
  • IF - NCOR1 Antibody AO1216a
    Figure 2: Confocal immunofluorescence analysis of methanol fixed Hela cells were transfected with pMX construct of human LIN28, cells were analyzed ~62 hours after transfection.
  • IF - NCOR1 Antibody AO1216a
    Figure 3: Confocal immunofluorescence analysis of NTERA-2 cells using anti-LIN28 mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75376
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7A7A9
Isotype IgG1
Calculated MW 270210 Da
Description NCOR1: Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
Immunogen Purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 9611
Other Names Nuclear receptor corepressor 1, N-CoR, N-CoR1, NCOR1, KIAA1047
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNCOR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCOR1
Synonyms KIAA1047
Function Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00624}
Research Areas
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1. Mol Cell Biol. 2005 Aug;25(15):6404-14. 2. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1471-80.

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$ 385.00
Cat# AO1216a
(40 western blots)
Availability: 7-10 days
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