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NCOR1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | O75376 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 7A7A9 |
| Isotype | IgG1 |
| Calculated MW | 270210 Da |
| Description | NCOR1: Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. |
| Immunogen | Purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 9611 |
|---|---|
| Other Names | Nuclear receptor corepressor 1, N-CoR, N-CoR1, NCOR1, KIAA1047 |
| Dilution | WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 ICC~~1:200~~1000 IF~~1:200~1000. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NCOR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCOR1 |
|---|---|
| Synonyms | KIAA1047 |
| Function | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Mol Cell Biol. 2005 Aug;25(15):6404-14. 2. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1471-80.
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$ 385.00
Cat# AO1216a
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