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Cytokeratin 19 AntibodyMouse Monoclonal Antibody to Cytokeratin 19
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AO1226a | 0.1ml 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Backgrounds
Cytokeratin 19 Antibody - Product info | |
| Application | WB, IHC
|
| Primary Accession | P08727 |
| Other Accession | NP_002267.2 |
| Reactivity | Human |
| Isotype | Mouse IgG1 |
| Clone Names | 9H8G6 |
| Calculated MW | 44106 Da |
Cytokeratin 19 Antibody - Additional info | |
| Gene ID 3880 | |
| Other Names CK19; K1CS; MGC15366; KRT19 | |
| Target/Specificity Purified recombinant fragment of Cytokeratin 19(aa80-400) expressed in E. Coli. | |
| Dilution WB~~1:500 - 2000. IHC~~1:200 - 1000. | |
| Format Purified recombinant fragment of Cytokeratin 19(aa80-400) expressed in E. Coli. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Cytokeratin 19 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Cytokeratin 19 Antibody - Protein Information | |
| Name KRT19 | |
| Function Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle | |
| Tissue Location Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin | |
Cytokeratin 19 Antibody - Related products
AP2823b: KRT19 Antibody (C-term)
AP2823c: KRT19 Antibody (Center)
AP3631a: Phospho-KRT19-pS46 Antibody
RI12958: KRT19 predesign siRNA
LY10852a: KRT19 Over-expression Lysate
BP2823a: KRT19 Antibody (S46) Blocking Peptide
BP2823b: KRT19 Antibody (C-term) Blocking Peptide
BP2823c: KRT19 Antibody (Center) Blocking Peptide
BP3631a: Phospho-KRT19-pS46 Antibody Blocking Peptide
AO1226a: Cytokeratin 19 Antibody
AO1239a: Cytokeratin 19 Antibody
AJ1224a: Cytokeratin-19 Antibody
Cytokeratin 19 Antibody - Application data
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Figure 1: Western blot analysis using anti-KRT19 monoclonal antibody against truncated KRT19-His recombinant protein(1) and full-length KRT19(aa1-400)-hIgGFc transfected CHO-K1 cell lysate(2).
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Figure 2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma(A), lung cancer(B) and normal colon tissue(C), showing cytoplasmic localization with DAB staining using anti-KRT19 antibody.
Cytokeratin 19 Antibody - Research Areas
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BACKGROUND
Cytokeratin 19, also known as KRT19, CK19, CK19, K1CS, MGC15366. Entrez Protein NP_002267. It is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis.
REFERENCES
1. Lung Cancer. 2007 Dec;58(3):369-75.
2. Endocr Pract. 2008 Mar;14(2):168-74.
