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Oct4 AntibodyMouse Monoclonal Antibody to Oct4
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AO1234a | 0.1ml 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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Oct4 Antibody - Product info | |
| Application | WB
|
| Primary Accession | Q01860 |
| Other Accession | NP_976034.3 |
| Reactivity | Human |
| Isotype | Mouse IgG1 |
| Clone Names | 1D10H6 |
| Calculated MW | 38571 Da |
Oct4 Antibody - Additional info | |
| Gene ID 5460 | |
| Other Names OCT3; OTF3; OTF4; MGC22487; POU5F1 | |
| Target/Specificity Purified recombinant fragment of Oct4(aa193-360) expressed in E. Coli. | |
| Dilution WB~~1:500 - 2000. | |
| Format Purified recombinant fragment of Oct4(aa193-360) expressed in E. Coli. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Oct4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Oct4 Antibody - Protein Information | |
| Name POU5F1 | |
| Synonyms OCT3, OCT4, OTF3 | |
| Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency | |
| Cellular Location Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern | |
| Tissue Location Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues | |
Oct4 Antibody - Related products
AP11546a: OCT3/4 Antibody (C279)
AP2046a: OCT4 (OCT3) Antibody (N-term)
AP2046c: OCT4 (OCT3) Antibody (E125)
AP3724a: Phospho-OCT4- S236 Antibody
RI14131: POU5F1 predesign siRNA
BP2046a: OCT3 (OCT4) Antibody (N-term) Blocking Peptide
BP2046c: OCT3/4 Antibody (E125) Blocking Peptide
BP2046d: OCT3/4 Antibody (S136) Blocking Peptide
Oct4 Antibody - Application data
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Figure 1: Western blot analysis using anti-Oct4 monoclonal antibody against recombinant Oct4 protein with Trx tag(1).
Oct4 Antibody - Research Areas
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BACKGROUND
Oct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, also known as POU5F1(POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Entrez Protein NP_002692. Oct-3/4 sustains stem-cell selfrenewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.
REFERENCES
1. Cells Tissues Organs. 2006;184(3-4):105-16.
2. Int J Cancer. 2007 Apr 1;120(7):1598-602.
