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SYT1 Antibody

Purified Mouse Monoclonal Antibody

  • WB - SYT1 Antibody AO1235a
    Figure 1: Western blot analysis using SYT1 mouse mAb against truncated Trx-SYT1 recombinant protein (1).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21579
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8G11B10
Isotype IgG1
Calculated MW 47573 Da
Description SYT1: synaptotagmin I. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse.
Immunogen Purified recombinant fragment of SYT1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 6857
Other Names Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYT1
Synonyms SVP65, SYT
Function May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules
Research Areas
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1. Cell. 2005 Sep 23;122(6):957-68. 2. FASEB J. 2008 Jun;22(6):2045-52.

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$ 325.00
Cat# AO1235a
(40 western blots)
Availability: 7-10 days
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