|Application ||WB, E|
|Clone Names||1D9G2; 1D9G4; 2B4G3|
|Calculated MW||51681 Da|
|Description||CHIT1:chitinase 1 (chitotriosidase). Chitotriosidase is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18. It is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.|
|Immunogen||Purified recombinant fragment of CHIT1 (aa22-137) expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Chitotriosidase-1, 126.96.36.199, Chitinase-1, CHIT1|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHIT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.|
|Cellular Location||Secreted. Lysosome. Note=A small proportion is lysosomal|
|Tissue Location||Detected in spleen. Secreted by cultured macrophages.|
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Provided below are standard protocols that you may find useful for product applications.
1. Sarcoidosis Vasc Diffuse Lung Dis. 2007 Mar;24(1):59-64. 2. Clin Biochem. 2007 Mar;40(5-6):365-9.
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