|Application ||WB, IHC, E|
|Description||ApoO: apolipoprotein O, also known as MYO25, FAM121B, MGC4825. Entrez Protein NP_077027. It is a chrondroitin-sulfate chain containing member of the apolipoprotein family and is an original glycoprotein up-regulated by diabetes in human Heart. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.|
|Immunogen||Purified recombinant fragment of ApoO expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Apolipoprotein O, Protein FAM121B, APOO, FAM121B|
|Dilution||WB~~1/500 - 1/2000|
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ApoO Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.|
|Cellular Location||Membrane; Single-pass membrane protein. Secreted|
|Tissue Location||Expressed in all tissues examined. Up- regulated in diabetic heart.|
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1. J Biol Chem. 2006 Nov 24;281(47):36289-302. 2. Genome Res. 2003 Oct;13(10):2265-70.
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