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LPL Antibody

Purified Mouse Monoclonal Antibody

  • WB - LPL Antibody AO1272a
    Figure 1: Western blot analysis using LPL mouse mAb against Hela cell lysate (1).
  • IHC - LPL Antibody AO1272a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human esophageal cancer (left) and lung cancer (right), showing nuclear localization using p53 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06858
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2C5
Isotype IgG1
Calculated MW 53.1kDa
Description LPL: lipoprotein lipase, also known as LIPD, HDLCQ11. Entrez Protein: NP_000228. It is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
Immunogen Purified recombinant fragment of LPL expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 4023
Other Names Lipoprotein lipase, LPL,, LPL, LIPD
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLPL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LPL
Synonyms LIPD
Function The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity).
Research Areas
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1. Obesity (Silver Spring). 2008 Jan;16(1):199-201. 2. Hum Mutat. 2009 Jan;30(1):49-55.

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$ 325.00
Cat# AO1272a
(40 western blots)
Availability: 7-10 days
Bulk Size
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