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MYL3 Antibody

Mouse Monoclonal Antibody to MYL3

  • WB - MYL3 Antibody AO1275b
    Figure 1: Western blot analysis using MYL3 (1) and MYL2 (2) mouse mAb against rat fetal heart tissues lysate.
  • IHC - MYL3 Antibody AO1275b
    Figure 2: Immunohistochemical analysis of paraffin-embedded human skeletal muscle (left) and cardiac muscle (right) using MYL3 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08590
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7C1
Isotype Mouse IgG1
Calculated MW 21932 Da
Description Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Immunogen Purified recombinant fragment of MYL3 expressed in E. Coli.
Additional Information
Gene ID 4634
Other Names Myosin light chain 3, Cardiac myosin light chain 1, CMLC1, Myosin light chain 1, slow-twitch muscle B/ventricular isoform, MLC1SB, Ventricular/slow twitch myosin alkali light chain, MYL3
Target/Specificity Purified recombinant fragment of MYL3 expressed in E. Coli.
Dilution WB~~1:500~~2000
Format Ascitic fluid containing 0.03% sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYL3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYL3
Function Regulatory light chain of myosin. Does not bind calcium.
Research Areas
Citations (0)

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1. Xie B, et al. Biophys Chem. 2003 Oct 1;106(1):57-66.

2. Haase H, et al. FASEB J. 2006 May;20(7):865-73.

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$ 385.00
Cat# AO1275b
(40 western blots)
Availability: 7-10 days
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