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SOD1 Antibody

Mouse Monoclonal Antibody to SOD1

Country
United States
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Ordering Information
Catalog # Size Availability Price  
AO1280a 0.1ml 7-10 days $ 325.00 Add to cart
  • Specification
  • Citations : 0
  • Reviews
  • Protocols
  • Background

SOD1 Antibody - Product info

ApplicationWB, IF
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
Primary AccessionP00441
Other AccessionNP_000445.1
ReactivityHuman, Mouse
IsotypeMouse IgG1
Clone Names6F5
Calculated MW15936 Da

SOD1 Antibody - Additional info

Gene ID 6647
Other Names
ALS; SOD; ALS1; IPOA; homodimer
Target/Specificity
Purified recombinant fragment of human SOD1 expressed in E. Coli.
Dilution
WB~~1:500~2000.
IF~~1:200~1000.
Format
Ascitic fluid containing 0.03% sodium azide.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
SOD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

SOD1 Antibody - Protein Information

Name SOD1
Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Cellular Location
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria

SOD1 Antibody - Related products

AP8733c: SOD1 Antibody (Center)

BP8733c: SOD1 Antibody (Center) Blocking Peptide

AJ1729b: SOD1 Antibody

AJ1729c: SOD1 Antibody

SOD1 Antibody - Research Areas

Application data

  • WB - SOD1 Antibody AO1280a

    Figure 1: Western blot analysis using anti-SOD1 mAb against Hela (1), NIH/3T3 (2), A549 (3) and A431 (4) cell lysate.

  • IF - SOD1 Antibody AO1280a

    Figure 2: Confocal immunofluorescence analysis of PANC-1 (left) and SKBR-3 (right) cells using anti-SOD1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

  • IF - SOD1 Antibody AO1280a

    Figure 3: Confocal immunofluorescence analysis of 3T3-L1 cells using anti-SOD1 mAb (green). Blue: DRAQ5 fluorescent DNA dye.

  • WB - SOD1 Antibody AO1280a
  • IF - SOD1 Antibody AO1280a
  • IF - SOD1 Antibody AO1280a

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

SOD1 (superoxide dismutase 1, soluble), also known as ALS. The protein binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis (ALS), a progressive degenerative disease of motor neurons. Rare transcript variants have been reported for this gene.

REFERENCES

1. Apoptosis. 2005 May;10(3):499-502.

2. Hum Mol Genet. 2008 Nov 1;17(21):3303-17.