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SOD1 AntibodyMouse Monoclonal Antibody to SOD1

Country
United States
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Ordering Information
Catalog # Size Availability Price  
AO1280a 0.1ml 7-10 days $ 325.00 Add to cart
  • Specification
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SOD1 Antibody - Product info

ApplicationWB, IF
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
Primary AccessionP00441
Other AccessionNP_000445.1
ReactivityHuman, Mouse
IsotypeMouse IgG1
Clone Names6F5
Calculated MW15936 Da

SOD1 Antibody - Additional info

Gene ID 6647
Other Names
ALS; SOD; ALS1; IPOA; homodimer
Target/Specificity
Purified recombinant fragment of human SOD1 expressed in E. Coli.
Dilution
WB~~1:500~2000.
IF~~1:200~1000.
Format
Ascitic fluid containing 0.03% sodium azide.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
SOD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

SOD1 Antibody - Protein Information

Name SOD1
Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Cellular Location
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria

SOD1 Antibody - Related products

AP8733c: SOD1 Antibody (Center)

BP8733c: SOD1 Antibody (Center) Blocking Peptide

AJ1729b: SOD1 Antibody

AJ1729c: SOD1 Antibody

SOD1 Antibody - Application data

  • Figure 1: Western blot analysis using anti-SOD1 mAb against Hela (1), NIH/3T3 (2), A549 (3) and A431 (4) cell lysate.

  • Figure 2: Confocal immunofluorescence analysis of PANC-1 (left) and SKBR-3 (right) cells using anti-SOD1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

  • Figure 3: Confocal immunofluorescence analysis of 3T3-L1 cells using anti-SOD1 mAb (green). Blue: DRAQ5 fluorescent DNA dye.

SOD1 Antibody - Research Areas

AntibodiesGene OntologyBiological ProcessApoptosisAgingCell DeathCell DifferentiationEmbryonic DevelopmentNeurogenesisOrgan DevelopmentSignal TransductionProtein Amino Acid PhosphorylationPost-translational Protein ModificationPhosphate Metabolic ProcessPhosphorus Metabolic ProcessPhosphorylationProtein Modification ProcessBiopolymer ModificationMetabolic ProcessPrimary Metabolic ProcessProtein Metabolic ProcessCellular Protein Metabolic ProcessCellular Metabolic ProcessCellular ProcessPositive Regulation Of Biological ProcessPositive Regulation Of Cellular ProcessRegulation Of Cell DeathRegulation Of Programmed Cell DeathResponse To Organic SubstanceRegulation Of ApoptosisRegulation Of PhosphorylationNegative Regulation Of Cellular ProcessNegative Regulation Of Biological ProcessResponse To Chemical StimulusRegulation Of Phosphate Metabolic ProcessRegulation Of Phosphorus Metabolic ProcessSystem DevelopmentMacromolecule Metabolic ProcessIntracellular Signaling CascadeProtein Kinase CascadeMulticellular Organismal DevelopmentAnatomical Structure DevelopmentNegative Regulation Of ApoptosisRegulation Of Kinase ActivityNegative Regulation Of Cell DeathNegative Regulation Of Programmed Cell DeathRegulation Of Protein Kinase ActivityDevelopmental ProcessRegulation Of Transferase ActivityCellular Macromolecule Metabolic ProcessRegulation Of Molecular FunctionCellular Amino Acid And Derivative Metabolic ProcessCatabolic ProcessPositive Regulation Of Molecular FunctionRegulation Of Biological QualityPositive Regulation Of Cell DeathPositive Regulation Of ApoptosisPositive Regulation Of Programmed Cell DeathRegulation Of Catalytic ActivityAnatomical Structure MorphogenesisRegulation Of Cell CommunicationRegulation Of MAP Kinase ActivityPositive Regulation Of Catalytic ActivityPositive Regulation Of Kinase ActivityPositive Regulation Of Protein Kinase ActivityRegulation Of Multicellular Organismal ProcessMAPKKK CascadeResponse To Extracellular StimulusRegulation Of Signal TransductionOxidation ReductionPositive Regulation Of Transferase ActivityResponse To Nutrient LevelsRegulation Of Immune System ProcessOrgan MorphogenesisResponse To StressPositive Regulation Of Multicellular Organismal ProcessNegative Regulation Of Metabolic ProcessCellular Catabolic ProcessNervous System DevelopmentReproductive Structure DevelopmentPositive Regulation Of MAP Kinase ActivityDeathCellular Response To StimulusProgrammed Cell DeathAnti-apoptosisResponse To External StimulusCofactor Metabolic ProcessSex DifferentiationReproductive Developmental ProcessGeneration Of NeuronsRegulation Of Metabolic ProcessRegulation Of Developmental ProcessCellular Component OrganizationHomeostatic ProcessRegulation Of Neuron ApoptosisResponse To DrugCellular Developmental ProcessRegulation Of Cytokine ProductionNeuron DifferentiationDevelopment Of Primary Sexual CharacteristicsGonad DevelopmentCell DevelopmentRegulation Of Blood PressureResponse To Oxidative StressCellular Amino Acid Derivative Metabolic ProcessRegulation Of Cellular Metabolic ProcessRegulation Of Lipid Metabolic ProcessRegulation Of Cell DifferentiationCellular Response To StressLeukocyte HomeostasisCoenzyme Metabolic ProcessCell CommunicationOvulation CycleSensory Organ DevelopmentActivation Of MAPK ActivityResponse To WoundingMulti-organism ProcessOvulation Cycle ProcessNegative Regulation Of Lipid Metabolic ProcessBiological RegulationRegulation Of GrowthBlood CirculationCirculatory System ProcessRegulation Of System ProcessResponse To Abiotic StimulusNegative Regulation Of Multicellular Organismal ProcessChemical HomeostasisSulfur Metabolic ProcessHomeostasis Of Number Of CellsResponse To EthanolFemale Gonad DevelopmentOrganelle OrganizationPlacenta DevelopmentNeuron DevelopmentRegulation Of Primary Metabolic ProcessResponse To Hydrogen PeroxideImmune System DevelopmentRegulation Of Biological ProcessRegulation Of T Cell ActivationFemale Sex DifferentiationDevelopment Of Primary Female Sexual CharacteristicsBiosynthetic ProcessReproductionMacromolecule Catabolic ProcessResponse To Inorganic SubstanceMulticellular Organismal ProcessReproductive ProcessHemopoietic Or Lymphoid Organ DevelopmentResponse To StimulusCellular Biosynthetic ProcessRegulation Of Lipid Biosynthetic ProcessNegative Regulation Of Biosynthetic ProcessFemale PregnancyCell Projection OrganizationCellular Macromolecule Catabolic ProcessRegulation Of Lymphocyte ActivationRhythmic ProcessResponse To Reactive Oxygen SpeciesRegulation Of Multicellular Organism GrowthRegulation Of Cell ActivationCellular HomeostasisDNA Catabolic ProcessImmune System ProcessRegulation Of Leukocyte ActivationRegulation Of Cellular ProcessNitrogen Compound Metabolic ProcessVascular Process In Circulatory SystemNegative Regulation Of Neuron ApoptosisOxygen And Reactive Oxygen Species Metabolic ProcessPeripheral Nervous System DevelopmentResponse To Temperature StimulusCellular Chemical HomeostasisGlutathione Metabolic ProcessMulticellular Organismal HomeostasisEmbryonic MorphogenesisCellular Nitrogen Compound Metabolic ProcessCellular Iron Ion HomeostasisAnatomical Structure HomeostasisOvarian Follicle DevelopmentCell Structure Disassembly During ApoptosisCellular Ion HomeostasisIon HomeostasisRegulation Of Blood Vessel SizeRegulation Of Tube SizeNegative Regulation Of Lipid Biosynthetic ProcessDNA Catabolic Process, EndonucleolyticResponse To HeatIron Ion HomeostasisRegulation Of Steroid Metabolic ProcessCation HomeostasisPositive Regulation Of Cytokine ProductionCell Morphogenesis Involved In DifferentiationEmbryonic Organ DevelopmentEar DevelopmentCellular Cation HomeostasisRegulation Of Smooth Muscle ContractionDi-, Tri-valent Inorganic Cation HomeostasisCell Morphogenesis Involved In Neuron DifferentiationTransmission Of Nerve ImpulseCell MorphogenesisCellular CompartmentCytoplasmExtracellular SpaceMitochondrial LumenMitochondrial MatrixNucleusPeroxisomeIntracellular PartIntracellularCytoplasmic PartMembrane-bounded OrganelleIntracellular Membrane-bounded OrganelleMembrane-enclosed LumenOrganelle LumenCytosolOrganelleIntracellular OrganelleIntracellular Organelle LumenOrganelle PartIntracellular Organelle PartMitochondrionMitochondrial PartNeuron ProjectionCell ProjectionVesicleDendriteCell SomaCytoplasmic VesicleExtracellular Region PartMicrobodyMacromolecular ComplexProtein ComplexMolecular FunctionCatalytic ActivityProtein BindingIdentical Protein BindingProtein Dimerization ActivityProtein Homodimerization ActivityEnzyme BindingOxidoreductase ActivityProtein Phosphatase BindingDiseaseBreast CancerDiabetes, Type 2Diabetes, Type 2; Liver DiseaseTissueColonFetal Brain CortexPlacenta

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BACKGROUND

SOD1 (superoxide dismutase 1, soluble), also known as ALS. The protein binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis (ALS), a progressive degenerative disease of motor neurons. Rare transcript variants have been reported for this gene.

REFERENCES

1. Apoptosis. 2005 May;10(3):499-502.

2. Hum Mol Genet. 2008 Nov 1;17(21):3303-17.