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SOD1 Antibody

Mouse Monoclonal Antibody to SOD1

     
  • WB - SOD1 Antibody AO1280a
    Figure 1: Western blot analysis using SOD1 mouse mAb against Hela (1), NIH/3T3 (2), A549 (3) and A431 (4) cell lysate.
  • FC - SOD1 Antibody AO1280a
    Figure 4: Flow cytometric analysis of A431 cells using SOD1 mouse mAb (green) and negative control (purple).
  • ICC - SOD1 Antibody AO1280a
    Figure 2: Confocal immunofluorescence analysis of PANC-1 (left) and SKBR-3 (right) cells using SOD1 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
  • IF - SOD1 Antibody AO1280a
    Figure 2: Confocal immunofluorescence analysis of PANC-1 (left) and SKBR-3 (right) cells using anti-SOD1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
  • IF - SOD1 Antibody AO1280a
    Figure 3: Confocal immunofluorescence analysis of 3T3-L1 cells using anti-SOD1 mAb (green). Blue: DRAQ5 fluorescent DNA dye.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, ICC, E
Primary Accession P00441
Other Accession NP_000445.1
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names 6F5
Calculated MW 15936 Da
Description SOD1 (superoxide dismutase 1, soluble), also known as ALS. The protein binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis (ALS), a progressive degenerative disease of motor neurons. Rare transcript variants have been reported for this gene.
Immunogen Purified recombinant fragment of human SOD1 expressed in E. Coli.
Additional Information
Gene ID 6647
Other Names Superoxide dismutase [Cu-Zn], Superoxide dismutase 1, hSod1, SOD1
Dilution WB~~1:500~~2000
FC~~1:200~~400
ICC~~1:200~~1000
IF~~1:200~1000.
Format Ascitic fluid containing 0.03% sodium azide.
Protein Information
Name SOD1
Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria
Research Areas
Citations (0)

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References

1. Apoptosis. 2005 May;10(3):499-502.

2. Hum Mol Genet. 2008 Nov 1;17(21):3303-17.

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$ 325.00
Cat# AO1280a
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(40 western blots)
Availability: 7-10 days
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