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SOD1 AntibodyMouse Monoclonal Antibody to SOD1
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AO1280a | 0.1ml 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
SOD1 Antibody - Product info | |
| Application | WB, IF
|
| Primary Accession | P00441 |
| Other Accession | NP_000445.1 |
| Reactivity | Human, Mouse |
| Isotype | Mouse IgG1 |
| Clone Names | 6F5 |
| Calculated MW | 15936 Da |
SOD1 Antibody - Additional info | |
| Gene ID 6647 | |
| Other Names ALS; SOD; ALS1; IPOA; homodimer | |
| Target/Specificity Purified recombinant fragment of human SOD1 expressed in E. Coli. | |
| Dilution WB~~1:500 - 2000. IF~~1:200 - 1000. | |
| Format Purified recombinant fragment of human SOD1 expressed in E. Coli. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SOD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
SOD1 Antibody - Protein Information | |
| Name SOD1 | |
| Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems | |
| Cellular Location Cytoplasm. Note=The pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria | |
SOD1 Antibody - Related products
AP8733c: SOD1 Antibody (Center)
LY11098a: SOD1 Over-expression Lysate
SOD1 Antibody - Application data
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Figure 1: Western blot analysis using anti-SOD1 mAb against Hela (1), NIH/3T3 (2), A549 (3) and A431 (4) cell lysate.
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Figure 2: Confocal immunofluorescence analysis of PANC-1 (left) and SKBR-3 (right) cells using anti-SOD1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
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Figure 3: Confocal immunofluorescence analysis of 3T3-L1 cells using anti-SOD1 mAb (green). Blue: DRAQ5 fluorescent DNA dye.
SOD1 Antibody - Research Areas
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BACKGROUND
SOD1 (superoxide dismutase 1, soluble), also known as ALS. The protein binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis (ALS), a progressive degenerative disease of motor neurons. Rare transcript variants have been reported for this gene.
REFERENCES
1. Apoptosis. 2005 May;10(3):499-502.
2. Hum Mol Genet. 2008 Nov 1;17(21):3303-17.
