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AAT AntibodyMouse Monoclonal Antibody to AAT
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AO1281a | 0.1ml 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
AAT Antibody - Product info | |
| Application | WB
|
| Primary Accession | P01009 |
| Other Accession | NP_001121179.1 |
| Reactivity | Human, Mouse |
| Isotype | Mouse IgG1 |
| Clone Names | 2B12 |
| Calculated MW | 46737 Da |
AAT Antibody - Additional info | |
| Gene ID 5265 | |
| Other Names PI; A1A; AAT; PI1; A1AT; SERPINA1 | |
| Target/Specificity Purified recombinant fragment of human AAT expressed in E. Coli. | |
| Dilution WB~~1:500 - 2000. | |
| Format Purified recombinant fragment of human AAT expressed in E. Coli. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AAT Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
AAT Antibody - Protein Information | |
| Name SERPINA1 | |
| Synonyms AAT, PI | |
| Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin | |
| Cellular Location Secreted. | |
| Tissue Location Plasma. | |
AAT Antibody - Related products
AP9431a: SERPINA1 Antibody (N-term)
AP9431d: SERPINA1 Antibody (Center)
BP9431a: SERPINA1 Antibody (N-term) Blocking Peptide
AAT Antibody - Application data
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Figure 1: Western blot analysis using anti-AAT mAb against human plasma (1) and NIH/3T3 cell lysate (2).
AAT Antibody - Research Areas
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BACKGROUND
AAT, also known as SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1. It is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Severe Serpin A1 deficiency leads to several clinical complications such as pulmonary emphysema, juvenile hepatisis, cirrhosis and hepatocellular carcinoma.
REFERENCES
1. J Proteome Res. 2005 Nov-Dec;4(6):2070-80.
2. Neuro Endocrinol Lett. 2008 Aug;29(4):482-4.
