|Application ||IHC, ICC, E|
|Description||REG1A (regenerating islet-derived 1 alpha), also known as PTP, PSP, is a member of the Reg family of secreted proteins with a C-type lectin domain. REG1A is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis.Due to variable glycosylation, pancreatic REG1A exists as multiple species of 16 - 18 kDa. REG1A promotes the maintenance and growth of pancreatic islet β-cells and intestinal villi. It is upregulated in pancreatitis and some carcinomas. REG1A is an antigenic target in autoimmune diabetes.|
|Immunogen||Purified recombinant fragment of human REG1A fused with hIgGFc tag expressed in HEK293 cell line.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Lithostathine-1-alpha, Islet cells regeneration factor, ICRF, Islet of Langerhans regenerating protein, REG, Pancreatic stone protein, PSP, Pancreatic thread protein, PTP, Regenerating islet-derived protein 1-alpha, REG-1-alpha, Regenerating protein I alpha, REG1A, PSPS, PSPS1, REG|
|Dilution||IHC~~1/200 - 1/1000|
IF~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||REG1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PSPS, PSPS1, REG|
|Function||Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.|
|Tissue Location||In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients|
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Provided below are standard protocols that you may find useful for product applications.
1. Pancreas. 2004 Jul;29(1):14-21. 2. Int J Cancer. 2008 Jul 15;123(2):409-13.
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