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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RTN3 Antibody   

RTN3 Antibody

Purified Mouse Monoclonal Antibody

     
  • IHC - RTN3 Antibody AO1297a
    Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and breast cancer (right) using RTN3 mouse mAb with DAB staining.
  • IHC - RTN3 Antibody AO1297a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human Liver tissues using RTN3 mouse mAb
  • ICC - RTN3 Antibody AO1297a
    Figure 1: Confocal immunofluorescence analysis of Hela (A), A431 (B) and THP-1 (C) cells using RTN3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
  • IF - RTN3 Antibody AO1297a
    Figure 1: Confocal immunofluorescence analysis of Hela (A), A431 (B) and THP-1 (C) cells using anti-RTN3 monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession O95197
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 10A8
Isotype IgG2a
Calculated MW 113kDa
Description RTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.
Immunogen Purified recombinant fragment of RTN3 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 10313
Other Names Reticulon-3, Homolog of ASY protein, HAP, Neuroendocrine-specific protein-like 2, NSP-like protein 2, Neuroendocrine-specific protein-like II, NSP-like protein II, NSPLII, RTN3, ASYIP, NSPL2
Dilution IHC~~1/200 - 1/1000
ICC~~1:200~~1000
IF~~1:200~1000.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRTN3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RTN3
Synonyms ASYIP, NSPL2
Function May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).
Cellular Location Endoplasmic reticulum membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma.
Research Areas
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References

1. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1198-205. 2. Brain Res Mol Brain Res. 2005 Aug 18;138(2):236-43. 3. FASEB J. 2003 Jul;17(10):1238-47.

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$ 300.00
Cat# AO1297a
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