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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GATA4 Antibody   

GATA4 Antibody

Purified Mouse Monoclonal Antibody

  • WB - GATA4 Antibody AO1301a
    Figure 1: Western blot analysis using GATA4 mouse mAb against rat fetal heart (1) and adult heart (2) tissues lysate.
  • IHC - GATA4 Antibody AO1301a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human colon cancer (A), gastric cancer (B) and rectal cancer (C) tissues using FOXA2 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43694
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Clone Names 6H10
Isotype IgG2b
Calculated MW 46kDa
Description GATA binding protein 4, also known as GATA4, it is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
Immunogen Purified recombinant fragment of human GATA4 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 2626
Other Names Transcription factor GATA-4, GATA-binding factor 4, GATA4
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGATA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GATA4
Function Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.
Cellular Location Nucleus
Research Areas
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1. J Mol Cell Cardiol. 2007 Dec;43(6):677-85.2. Mol Cell Biol. 2000 Oct;20(20):7550-8.3. EMBO J. 1997 Sep 15;16(18):5687-96.

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$ 385.00
Cat# AO1301a
(40 western blots)
Availability: 7-10 days
Bulk Size
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