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CD40 Antibody

Purified Mouse Monoclonal Antibody

  • IF - CD40 Antibody AO1304a
    Figure 1: Confocal immunofluorescence analysis of human peripheral blood lymphocyles (left) and mouse L1210 cells (right) using CD40 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P25942
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 9G10
Isotype IgG1
Calculated MW 30619 Da
Description CD40 molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Immunogen Purified recombinant fragment of CD40 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 958
Other Names Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5
Dilution IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD40 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD40
Synonyms TNFRSF5
Function Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Cellular Location Isoform I: Cell membrane; Single-pass type I membrane protein
Tissue Location B-cells and in primary carcinomas.
Research Areas
Citations (0)

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1. Clin Cancer Res. 2003 Feb;9(2):722-8. 2. Clin Cancer Res. 2003 Feb;9(2):619-24. 3. Immunity. 1999 Sep;11(3):339-48.

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$ 325.00
Cat# AO1304a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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