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NTRK3 AntibodyMouse Monoclonal Antibody to NTRK3
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AO1307a | 0.1ml 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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- Backgrounds
NTRK3 Antibody - Product info | |
| Application | WB
|
| Primary Accession | Q16288 |
| Other Accession | NP_002521.2 |
| Reactivity | Human |
| Isotype | Mouse IgG1 |
| Clone Names | 4G5 |
| Calculated MW | 94428 Da |
NTRK3 Antibody - Additional info | |
| Gene ID 4916 | |
| Other Names TRKC; gp145(trkC) | |
| Target/Specificity Purified recombinant extracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag expressed in HEK293 cells. | |
| Dilution WB~~1:500 - 2000. | |
| Format Purified recombinant extracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag expressed in HEK293 cells. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NTRK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
NTRK3 Antibody - Protein Information | |
| Name NTRK3 | |
| Synonyms TRKC | |
| Function Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain | |
NTRK3 Antibody - Related products
AP6818b: NTRK3 Antibody (C-term)
AP7688a: TRKC Antibody (N-term)
RI13699: NTRK3 predesign siRNA
LY11761a: NTRK3 Over-expression Lysate
BP6818b: NTRK3 Antibody (C-term) Blocking Peptide
NTRK3 Antibody - Application data
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Figure 1: Western blot analysis using anti-NTRK3 monoclonal antibody against extracellular domain of human NTRK3 (aa32-429).
NTRK3 Antibody - Research Areas
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BACKGROUND
NTRK3 (neurotrophic tyrosine kinase, receptor, type 3), it is a member of the neurotrophic tyrosine receptor kinase (NTRK) family and plays an important role in the development and maintenance of neural tissues. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
REFERENCES
1. BMC Cancer. 2007 Oct 31;7:202.
2. J Pathol. 2002 Aug;197(5):661-7.
