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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Proteinase 3 Antibody   

Proteinase 3 Antibody

Purified Mouse Monoclonal Antibody

  • WB - Proteinase 3 Antibody AO1309a
    Figure 1: Western blot analysis using PRTN3 mouse mAb against PRTN3 (aa28-256)-hIgGFc transfected HEK293 cell lysate (1).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24158
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3B4
Isotype IgG2b
Calculated MW 28kDa
Description Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Immunogen Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
Formulation Antibody are purified by protein G affinity chromatography.
Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Additional Information
Gene ID 5657
Other Names Myeloblastin,, AGP7, C-ANCA antigen, Leukocyte proteinase 3, PR-3, PR3, Neutrophil proteinase 4, NP-4, P29, Wegener autoantigen, PRTN3, MBN
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsProteinase 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRTN3
Synonyms MBN
Function Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
Research Areas
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1. Blood. 2007 Dec 1;110(12):4086-95. 2. Clin Exp Immunol. 2006 Jul;145(1):63-70.

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$ 325.00
Cat# AO1309a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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