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FOXA2 Antibody

Purified Mouse Monoclonal Antibody

  • WB - FOXA2 Antibody AO1311a
    Figure 1: Western blot analysis using FOXA2 mouse mAb against A549 (1) cell lysate.
  • IHC - FOXA2 Antibody AO1311a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human colon cancer (A), gastric cancer (B) and rectal cancer (C) tissues using FOXA2 mouse mAb with DAB staining.
  • FC - FOXA2 Antibody AO1311a
    Figure 4: Flow cytometric analysis of Hela cells using DAXX mouse mAb (green) and negative control (purple).
  • ICC - FOXA2 Antibody AO1311a
    Figure 2: Confocal immunofluorescence analysis of PANC-1 cells using DAXX mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
  • IF - FOXA2 Antibody AO1311a
    Figure 2: Confocal immunofluorescence analysis of PANC-1 cells using anti-DAXX mAb (green). Blue: DRAQ5 fluorescent DNA dye.
  • IF - FOXA2 Antibody AO1311a
    Figure 3: Confocal immunofluorescence analysis of Hela cells using anti-DAXX mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y261
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7H4B7
Isotype IgG1
Calculated MW 48kDa
Description FOXA2 (forkhead box A2), also known as HNF3B (hepatocyte nuclear factor 3, beta). It is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for FOXA2.
Immunogen Purified recombinant fragment of FOXA2 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3170
Other Names Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2, HNF3B, TCF3B
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOXA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXA2
Synonyms HNF3B, TCF3B
Function Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:14500912}. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus
Research Areas
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1. Hepatology. 2008 Aug;48(2):597-606. 2. Cancer Res. 2004 Jun 15;64(12):4137-47.

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$ 325.00
Cat# AO1311a
(40 western blots)
Availability: 7-10 days
Bulk Size
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