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NTRK3 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - NTRK3 Antibody AO1316a
    Figure 1: Western blot analysis using NTRK3 mouse mAb against extracellular domain of human NTRK3 (aa32-429).
  • IHC - NTRK3 Antibody AO1316a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using PGA5 mouse mAb with DAB staining.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q16288
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4G5
Isotype IgG1
Calculated MW 94kDa
Description NTRK3 (neurotrophic tyrosine kinase, receptor, type 3), it is a member of the neurotrophic tyrosine receptor kinase (NTRK) family and plays an important role in the development and maintenance of neural tissues. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
Immunogen Purified recombinant extracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag expressed in HEK293 cells.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 4916
Other Names NT-3 growth factor receptor, 2.7.10.1, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC
Dilution WB~~1/500 - 1/2000
IHC~~1:200~~1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNTRK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTRK3
Synonyms TRKC
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain
Research Areas
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References

1. BMC Cancer. 2007 Oct 31;7:202. 2. J Pathol. 2002 Aug;197(5):661-7.

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$ 325.00
Cat# AO1316a
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