|Application ||WB, FC, E|
|Description||MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.|
|Immunogen||Purified recombinant fragment of human MATK expressed in E. Coli.|
|Formulation||Antibody are purified by protein G affinity chromatography. |
Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
|Other Names||Megakaryocyte-associated tyrosine-protein kinase, 220.127.116.11, CSK homologous kinase, CHK, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, MATK, CTK, HYL|
|Dilution||WB~~1/500 - 1/2000|
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MATK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.|
|Cellular Location||Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation|
|Tissue Location||Expressed in various myeloid cell lines, detected in brain and lung|
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Provided below are standard protocols that you may find useful for product applications.
1. Int J Oncol. 2002 Jul;21(1):197-205. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Nat Genet. 2004 Jan;36(1):40-5.
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