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> home > Products > Primary Antibodies > Antibody Collections > Anti-Kinome Antibodies > MATK Antibody
MATK Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P42679 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 9D7 |
| Isotype | IgG1 |
| Calculated MW | 56kDa |
| Description | MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. |
| Immunogen | Purified recombinant fragment of human MATK expressed in E. Coli. |
| Formulation | Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50% glycerol and 0.03% sodium azide. |
| Gene ID | 4145 |
|---|---|
| Other Names | Megakaryocyte-associated tyrosine-protein kinase, 2.7.10.2, CSK homologous kinase, CHK, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, MATK, CTK, HYL |
| Dilution | WB~~1/500 - 1/2000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MATK Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MATK |
|---|---|
| Synonyms | CTK, HYL |
| Function | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC- family members in brain by specifically phosphorylating their C- terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T- cell proliferation. |
| Cellular Location | Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation |
| Tissue Location | Expressed in various myeloid cell lines, detected in brain and lung |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Int J Oncol. 2002 Jul;21(1):197-205. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Nat Genet. 2004 Jan;36(1):40-5.
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$ 325.00
Cat# AO1321a
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