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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MATK Antibody   

MATK Antibody

Purified Mouse Monoclonal Antibody

  • WB - MATK Antibody AO1321a
    Figure 1: Western blot analysis using MATK mouse mAb against K562 cell lysate (1).
  • FC - MATK Antibody AO1321a
    Figure 2: Flow cytometric analysis of K562 cells using MATK mouse mAb (green) and negative control (purple).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42679
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 9D7
Isotype IgG1
Calculated MW 56kDa
Description MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
Immunogen Purified recombinant fragment of human MATK expressed in E. Coli.
Formulation Antibody are purified by protein G affinity chromatography.
Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Additional Information
Gene ID 4145
Other Names Megakaryocyte-associated tyrosine-protein kinase,, CSK homologous kinase, CHK, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, MATK, CTK, HYL
Dilution WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMATK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CTK, HYL
Function Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Cellular Location Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation
Tissue Location Expressed in various myeloid cell lines, detected in brain and lung
Research Areas
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1. Int J Oncol. 2002 Jul;21(1):197-205. 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 3. Nat Genet. 2004 Jan;36(1):40-5.

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$ 325.00
Cat# AO1321a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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