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PGA5 Antibody

Purified Mouse Monoclonal Antibody

  • WB - PGA5 Antibody AO1326a
    Figure 1: Western blot analysis using PGA5 mouse mAb against HepG2 (1) and SMMC-7721 (2) cell lysate.
  • IHC - PGA5 Antibody AO1326a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using PGA5 mouse mAb with DAB staining.
  • FC - PGA5 Antibody AO1326a
    Figure 3: Flow cytometric analysis of Hela cells using ITGA5 mouse mAb (green) and negative control (purple).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P0DJD9
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2C1
Isotype IgG1
Calculated MW 42kDa
Description PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor,pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates.PGA5 is inhibited by ovUS-1, a uterine serpin.
Immunogen Purified recombinant fragment of human PGA5 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 5222
Other Names Pepsin A-5,, Pepsinogen-5, PGA5
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPGA5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PGA5
Function Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Cellular Location Secreted.
Research Areas
Citations (0)

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1. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 2. Nat Genet. 2004 Jan;36(1):40-5.

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$ 325.00
Cat# AO1326a
(40 western blots)
Availability: 7-10 days
Bulk Size
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