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ITGA5 Antibody

Purified Mouse Monoclonal Antibody

  • WB - ITGA5 Antibody AO1336a
    Figure 1: Western blot analysis using ITGA5 mouse mAb against ITGA5-hIgGFc transfected HEK293 cell lysate.
  • IHC - ITGA5 Antibody AO1336a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human Placenta tissues using ITGA5 mouse mAb
  • FC - ITGA5 Antibody AO1336a
    Figure 3: Flow cytometric analysis of Hela cells using ITGA5 mouse mAb (green) and negative control (purple).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08648
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 10F6
Isotype IgG2a
Calculated MW 114kDa
Description The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
Immunogen Purified recombinant fragment of human ITGA5 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3678
Other Names Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITGA5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA5
Synonyms FNRA
Function Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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1. Proc Natl Acad Sci USA. 1993. 90(22):10553-7 2. J Cell Biol. 1998. 143(7):2081-92 3. Mol Biol Cell. 2000. 11(9):3109-21 4. J Cell Biol. 2001. 152(1):65-73 5. J Biol Chem. 2002. 277(22):19800-5

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$ 325.00
Cat# AO1336a
(40 western blots)
Availability: 7-10 days
Bulk Size
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