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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CD38 Antibody   

CD38 Antibody

Purified Mouse Monoclonal Antibody

  • WB - CD38 Antibody AO1338a
    Figure 1: Western blot analysis using CD38 mouse mouse mAb against CD38-hIgGFc transfected HEK293 cell lysate.
  • IHC - CD38 Antibody AO1338a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), lymphonodus tissue (B),showing cytomembrane localization using CD38 mouse mAb with DAB staining.
  • IF - CD38 Antibody AO1338a
    Figure 2: Immunofluorescence analysis of PANC-1 (left) and Hela (right) cells using AKT2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28907
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6E12D
Isotype IgG1
Calculated MW 34kDa
Description CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.
Immunogen Purified recombinant fragment of human CD38 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 952
Other Names ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1,, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase,, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10, CD38, CD38
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD38 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD38
Function Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Cellular Location Membrane; Single-pass type II membrane protein
Tissue Location Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Research Areas
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1. Trends Biochem Sci. 1992 Dec;17(12):495. 2. J Cell Biol. 1999 Sep 6;146(5):1161-72. 3. Exp Hematol. 2002 Jun;30(6):582-9. 4. Mol Immunol. 2006 Mar;43(7):1029-39.

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$ 325.00
Cat# AO1338a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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