|Application ||WB, IHC, E|
|Description||ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (alsodesignated SPLA in rat), also regulates the transport of calcium in the Golgicomplex and is related to other P-type ATPases family members, such as thesarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calciumATPase (PCMA). ATP2C1 is a transmembrane protein that exists as twosplice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.|
|Immunogen||Purified recombinant fragment of ATP2C1 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Calcium-transporting ATPase type 2C member 1, ATPase 2C1, 220.127.116.11, ATP-dependent Ca(2+) pump PMR1, ATP2C1, KIAA1347, PMR1L|
|Dilution||WB~~1/500 - 1/2000|
IHC~~1/500 - 1/2000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP2C1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney|
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Provided below are standard protocols that you may find useful for product applications.
1. J Invest Dermatol. 2005 Nov;125(5):933-5. 2. J Dermatol Sci. 2006 Aug;43(2):150-1. 3. Dermatology. 2007;215(4):277-83.
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