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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Androgen receptor Antibody   

Androgen receptor Antibody

Purified Mouse Monoclonal Antibody

  • WB - Androgen receptor Antibody AO1360a
    Figure 1: Western blot analysis using Androgen receptor mouse mAb against K562 (1), Jurkat (2) and LNCaP (3) cell lysate.
  • WB - Androgen receptor Antibody AO1360a
    Figure 2: Western blot analysis using Androgen receptor mAb against human Androgen receptor (AA: 221-321) recombinant protein. (Expected MW is 40 kDa)
  • WB - Androgen receptor Antibody AO1360a
    Figure 3: Western blot analysis using Androgen receptor mouse mAb against Androgen receptor (aa221-321)-hIgGFc transfected HEK293 cell lysate.
  • IHC - Androgen receptor Antibody AO1360a
    Figure 4: Immunohistochemical analysis of paraffin-embedded human Prostate tissues using Androgen receptor mouse mAb
  • IHC - Androgen receptor Antibody AO1360a
    Figure 5: Immunohistochemical analysis of paraffin-embedded human human testis (left) and prostate cancer (right) tissues using Androgen Receptor mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10275
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2H8
Isotype IgG1
Calculated MW 110kDa
Description The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA binding transcription factor which regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype.
Immunogen Purified recombinant fragment of human AR expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 367
Other Names Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAndrogen receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AR
Synonyms DHTR, NR3C4
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1
Tissue Location Isoform 2 is mainly expressed in heart and skeletal muscle.
Research Areas
Citations (0)

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1. Chin Med J (Engl). 2009 Nov 20;122(22):2779-83. 2. Taiwan J Obstet Gynecol. 2009 Sep;48(3):262-7. 3. Prostate. 2008 Mar 1;68(4):453-61. 4. Cancer Res. 2007 May 15;67(10):4630-7.

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$ 325.00
Cat# AO1360a
(40 western blots)
Availability: 7-10 days
Bulk Size
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