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MAP2K2 Antibody

Purified Mouse Monoclonal Antibody

  • WB - MAP2K2 Antibody AO1362a
    Figure 1: Western blot analysis using MAP2K2 mouse mAb against PC-12 (1), Jurkat (2), Hela (3) and NIH/3T3 (4) cell lysate.
  • IF - MAP2K2 Antibody AO1362a
    Figure 2: Immunofluorescence analysis of Hela cells using anti-MAP2K2 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
  • FC - MAP2K2 Antibody AO1362a
    Figure 3: Flow cytometric analysis of Hela cells using anti-MAP2K2 mAb (green) and negative control (purple).
  • IHC - MAP2K2 Antibody AO1362a
    Figure 3: Immunohistochemical analysis of paraffin-embedded human Liver tissues using NKX3A mAb
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P36507
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 7F5
Isotype IgG1
Calculated MW 44kDa
Description MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
Immunogen Purified recombinant fragment of human MAP2K2 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 5605
Other Names Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2,, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MAP2K2, MEK2, MKK2, PRKMK2
Dilution WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP2K2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP2K2
Synonyms MEK2, MKK2, PRKMK2
Function Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
Citations (0)

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1. Mol Cell Biol. 1993 Aug;13(8):4679-90. 2. Eur J Biochem. 1995 Nov 15;234(1):32-8. 3. Oncogene. 1998 Jul 9;17(1):57-65.

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$ 325.00
Cat# AO1362a
(40 western blots)
Availability: 7-10 days
Bulk Size
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