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DKK3 Antibody

Purified Mouse Monoclonal Antibody

  • WB - DKK3 Antibody AO1363a
    Figure 1: Western blot analysis using DKK3 mouse mAb against HEK293 (1), MCF-7 (2) and HL7702 (3) cell lysate.
  • FC - DKK3 Antibody AO1363a
    Figure 2: Flow cytometric analysis of MCF-7 cells using anti-DKK3 mAb (green) and negative control (purple).
  • IHC - DKK3 Antibody AO1363a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human Thyroid tissues using HSPA5 mouse mAb
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBP4
Reactivity Human, Monkey
Host Mouse
Clonality Monoclonal
Clone Names 4G7
Isotype IgG1
Calculated MW 38kDa
Description Dkk-3 (Dickkopf-3) is a member of the dickkopf family. It is a 350 amino acid secreted glycoprotein that is composed of an N-terminal signal peptide and two conserved cysteine-richdomains, which are separated by a 12 amino acid linker region. This secreted protein is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene.
Immunogen Purified recombinant fragment of human DKK3 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 27122
Other Names Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, REIC
Dilution WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDKK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DKK3
Synonyms REIC
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Cellular Location Secreted.
Tissue Location Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4}
Citations (0)

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1. Virchows Arch. 2009 Jun;454(6):639-46. 2. Gene. 2002 Jan 9;282(1-2):151-8. 3. J Urol. 2004 Mar;171(3):1314-8.

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$ 325.00
Cat# AO1363a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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