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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   ZBTB7B Antibody   

ZBTB7B Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - ZBTB7B Antibody AO1364a
    Figure 1: Western blot analysis using ZBTB7B mAb against HEK293 (1,2) cell lysate.
  • IHC - ZBTB7B Antibody AO1364a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human Breast tissues using anti-ZBTB7B mouse mAb
  • IF - ZBTB7B Antibody AO1364a
    Figure 3: Immunofluorescence analysis of Hela cells using ZBTB7B mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession O15156
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7C12
Isotype lgG1
Calculated MW 58kDa
Description ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Immunogen Purified recombinant fragment of human ZBTB7B expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 51043
Other Names Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, hcKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zfp-67, Zinc finger protein 857B, Zinc finger protein Th-POK, ZBTB7B, ZBTB15, ZFP67, ZNF857B
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZBTB7B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZBTB7B
Synonyms ZBTB15, ZFP67, ZNF857B
Function Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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References

1.Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9372-6. 2.J Biol Chem. 2000 Sep 1;275(35):27421-38. 3.J Cell Biochem. 2009 Aug 15;107(6):1037-45. Review.

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$ 325.00
Cat# AO1364a
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