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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TCF3 Antibody   

TCF3 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - TCF3 Antibody AO1365a
    Figure 1: Western blot analysis using TCF3 mouse mAb against A549 (1), A431 (2), Hela (3), PANC-1 (4) and PC-3 (5) cell lysate.
  • FC - TCF3 Antibody AO1365a
    Figure 2: Flow cytometric analysis of A549 cells using anti-TCF3 mAb (green) and negative control (purple).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P15923
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6B8
Isotype IgG1
Calculated MW 67.6kDa
Description Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
Immunogen Purified recombinant fragment of human TCF3 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 6929
Other Names Transcription factor E2-alpha, Class B basic helix-loop-helix protein 21, bHLHb21, Immunoglobulin enhancer-binding factor E12/E47, Immunoglobulin transcription factor 1, Kappa-E2-binding factor, Transcription factor 3, TCF-3, Transcription factor ITF-1, TCF3, BHLHB21, E2A, ITF1
Dilution WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTCF3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCF3
Synonyms BHLHB21, E2A, ITF1
Function Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
Cellular Location Nucleus.
Research Areas
Citations (0)

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References

1.J Biol Chem. 2000 Oct 27;275(43):33567-73. 2.Mol Cell Biol. 2001 Mar;21(5):1866-73. 3.J Biol Chem. 2003 Jan 24;278(4):2370-6. Epub 2002 Nov 14.

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$ 325.00
Cat# AO1365a
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