CD247 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC, FC, ICC, E |
---|---|
Primary Accession | P20963 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 4B10 |
Isotype | IgG1 |
Calculated MW | 18kDa |
Description | The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
Immunogen | Purified recombinant fragment of human CD247 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Gene ID | 919 |
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Other Names | T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247, CD247, CD3Z, T3Z, TCRZ |
Dilution | IF~~1/200 - 1/1000 WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 FC~~1/200 - 1/400 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CD247 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD247 |
---|---|
Synonyms | CD3Z, T3Z, TCRZ |
Function | Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. |
Cellular Location | Membrane; Single-pass type I membrane protein |

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Provided below are standard protocols that you may find useful for product applications.
References
1. J Immunol. 2002 Aug 15;169(4):1705-12. 2. Arthritis Rheum. 2003 Jul;48(7):1948-55. 3. Nat Methods. 2005 Aug;2(8):591-8.

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