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Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | P20963 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4B10 |
| Isotype | IgG1 |
| Calculated MW | 18kDa |
| Description | The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Immunogen | Purified recombinant fragment of human CD247 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 919 |
|---|---|
| Other Names | T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247, CD247, CD3Z, T3Z, TCRZ |
| Dilution | IF~~1/200 - 1/1000 WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD247 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD247 |
|---|---|
| Synonyms | CD3Z, T3Z, TCRZ |
| Function | Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
1. J Immunol. 2002 Aug 15;169(4):1705-12. 2. Arthritis Rheum. 2003 Jul;48(7):1948-55. 3. Nat Methods. 2005 Aug;2(8):591-8.
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