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PRDM1 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - PRDM1 Antibody AO1373a
    Figure 1: Western blot analysis using PRDM1 mouse mAb against Raji (1, 2), L1210 (3) and TPH-1 (4) cell lysate.
  • IHC - PRDM1 Antibody AO1373a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A) and esophageal cancer (B), showing cytoplasmic localization using CDC2 mouse mAb with DAB staining.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75626
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 5E7
Isotype IgG1
Calculated MW 88kDa
Description PRDM1/Blimp1 is a repressor of beta-interferon gene expression. This action is exerted by binding to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. The transcription of this gene is increased upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
Immunogen Purified recombinant fragment of human PRDM1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 639
Other Names PR domain zinc finger protein 1, 2.1.1.-, BLIMP-1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, Positive regulatory domain I-binding factor 1, PRDI-BF1, PRDI-binding factor 1, PRDM1, BLIMP1
Dilution WB~~1/500 - 1/2000
IHC~~1:200~~1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRDM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRDM1
Synonyms BLIMP1
Function Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B- lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q60636}. Cytoplasm
Research Areas
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References

1. Nat Cell Biol. 2006 Jun;8(6):623-30. 2. Int J Hematol. 2007 Dec;86(5):429-37. 3. Nat Genet. 2008 Aug;40(8):955-62.

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$ 325.00
Cat# AO1373a
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