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CDKN1B AntibodyMouse Monoclonal Antibody to CDKN1B
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AO1379a | 0.1ml 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
CDKN1B Antibody - Product info | |
| Application | WB
|
| Primary Accession | P46527 |
| Other Accession | NP_004055.1 |
| Reactivity | Human |
| Isotype | Mouse IgG1 |
| Clone Names | 3D8 |
| Calculated MW | 22073 Da |
CDKN1B Antibody - Additional info | |
| Gene ID 1027 | |
| Other Names KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B | |
| Target/Specificity Purified recombinant fragment of human CDKN1B expressed in E. Coli. | |
| Dilution WB~~1:500 - 2000. | |
| Format Purified recombinant fragment of human CDKN1B expressed in E. Coli. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CDKN1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
CDKN1B Antibody - Protein Information | |
| Name CDKN1B | |
| Synonyms KIP1 | |
| Function Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry | |
| Cellular Location Nucleus. Cytoplasm. Endosome (By similarity). Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity) | |
| Tissue Location Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney | |
CDKN1B Antibody - Related products
AP10418a: 27Kip1-T157 Antibody
AP13302b: CDKN1B Antibody (C-term)
AP3191a: Phospho-p27Kip1-S10 Antibody
AP3192a: Phospho-p27Kip1-S178 Antibody
AP3193a: Phospho-p27Kip1-T157 Antibody
AP3194a: Phospho-p27Kip1-T187 Antibody
AP3529a: Phospho-p27Kip1-T198 Antibody
AP6269b: 27Kip1 Antibody (C-term)
RI10983: CDKN1B predesign siRNA
LY12364a: CDKN1B Over-expression Lysate
BP10418a: 27Kip1-T157 Antibody Blocking peptide
BP3191a: Phospho-p27Kip1-S10 Antibody Blocking Peptide
BP3192a: Phospho-p27Kip1-S178 Antibody Blocking Peptide
BP3193a: Phospho-p27Kip1-T157 Antibody Blocking Peptide
BP3194a: Phospho-p27Kip1-T187 Antibody Blocking Peptide
BP3529a: Phospho-p27Kip1-T198 Antibody Blocking Peptide
BP6269b: 27Kip1 Antibody (C-term) Blocking Peptide
AT1481a: CDKN1B Antibody (monoclonal) (M01)
AJ1569c: p27/Kip1 Antibody (C-term)
AJ1569d: p27/Kip1 Antibody Phospho (pS10)
CDKN1B Antibody - Application data
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Figure 1: Western blot analysis using CDKN1B mAb against CDKN1B-hIgGFc transfected HEK293 cell lysate.
CDKN1B Antibody - Research Areas
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BACKGROUND
p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
REFERENCES
1. Exp Mol Med. 2009 Nov 30;41(11):765-71.
2. Int J Gynecol Pathol. 2010 Jan;29(1):8-18.
