NKX3A Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, FC, E |
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Primary Accession | Q99801 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 4H4 |
Isotype | IgG2b |
Calculated MW | 26.3kDa |
Description | Nkx3.1 is a transcription factor that may play an important role in regulating proliferation of glandular epithelium and in the formation of ducts in the prostate. It has been thought to be one of the target genes of the 8p21 loss of heterozygosity, common in prostate cancer. But neither disruption of the coding region of the gene, nor mutations have been found in prostate cancer. |
Immunogen | Purified recombinant fragment of human NKX3A expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Gene ID | 4824 |
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Other Names | Homeobox protein Nkx-3.1, Homeobox protein NK-3 homolog A, NKX3-1, NKX3.1, NKX3A |
Dilution | WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 FC~~1/200 - 1/400 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NKX3A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NKX3-1 (HGNC:7838) |
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Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288} |
Tissue Location | Highly expressed in the prostate and, at a lower level, in the testis. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Exp Mol Med. 2006 Dec 31;38(6):625-33. 2. Exp Biol Med (Maywood). 2008 Mar;233(3):297-309. 3.Mol Biol Rep. 2010 Mar;37(3):1505-12.
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