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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ICAM1 Antibody   

ICAM1 Antibody

Purified Mouse Monoclonal Antibody

  • WB - ICAM1 Antibody AO1383a
    Figure 1: Western blot analysis using ICAM1 mouse mAb against ICAM1(AA: 28-480)-hIgGFc transfected HEK293 (1) cell lysate.
  • IHC - ICAM1 Antibody AO1383a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), colon cancer (B), breast cancer (C) and rectal cancer(D), using EPCAM mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05362
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6G12
Isotype IgG1
Calculated MW 57.8kDa
Description ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils), with lower levels that increase in inflammation. ICAM1 is also detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.
Immunogen Purified recombinant fragment of human ICAM1(28-480aa) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3383
Other Names Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54, ICAM1
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsICAM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ICAM1
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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1. J Neurosci Res. 1992 Feb;31(2):365-74. 2. J Cell Biol. 2002 Jun 24;157(7):1233-45. 3. J Hepatol. 2004 Mar;40(3):375-9.

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$ 325.00
Cat# AO1383a
(40 western blots)
Availability: 7-10 days
Bulk Size
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