|Application ||WB, E|
|Description||Mesp1 (mesoderm posterior 1) is a basic helix-loop-helix-type transcription factor, which along with its related proteins, has an essential role in both segmentation and rostro-caudal patterning of somites in the anterior pre-somitic mesoderm. Mesp1 is expressed in many of the precursors of the cardiovascular system and is known to play a role in the process of cardiac morphogenesis.|
|Immunogen||Purified recombinant fragment of human MESP1 expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide. |
|Other Names||Mesoderm posterior protein 1, Class C basic helix-loop-helix protein 5, bHLHc5, MESP1, BHLHC5|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MESP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).|
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1. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3859-64. 2. Cell Stem Cell. 2008 Jul 3;3(1):69-84. 3. Circulation. 2008 Jul 29;118(5):507-17.
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