|Application ||WB, E|
|Description||ETS variant 5,transcription factor of the ETS family,divergent member of the winged helix-turn-helix superfamily,expressed in brain,placenta and other tissues involved in development. Tissue specificity: Ubiquitous. ERM is expressed in Sertoli cells and spermatogonial stem cells (SSCs). Studies on knockout mice have shown that it is required for SSC self-renewal but not differentiation, thus affected mice exhibit progressive germ cell depletion.|
|Immunogen||Purified recombinant fragment of human ETV5 expressed in E. Coli. |
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||ETS translocation variant 5, Ets-related protein ERM, ETV5, ERM|
|Dilution||WB~~1/500 - 1/2000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ETV5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to DNA sequences containing the consensus nucleotide core sequence GGAA.|
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1. Immunity. 2002 Oct;17(4):401-12. 2. Clin Cancer Res. 2004 Nov 1;10(21):7297-303. 3. J Hum Genet. 2009 Dec;54(12):727-31.
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