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IHOG Antibody

Purified Mouse Monoclonal Antibody

  • WB - IHOG Antibody AO1410a
    Figure 1: Western blot analysis using IHOG mAb against IHOG-hIgGFc transfected HEK293 cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9VM64
Reactivity Drosophila
Host Mouse
Clonality Monoclonal
Clone Names 3G8
Isotype IgG1
Calculated MW 98kDa
Description The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
Immunogen Purified recombinant fragment of human IHOG expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 33972
Other Names Interference hedgehog, ihog
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIHOG Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ihog
Function Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).
Cellular Location Membrane; Single-pass type I membrane protein {ECO:0000255, ECO:0000269|PubMed:16630821}
Research Areas
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1. Cell. 2006 Apr 21;125(2):343-57. 2. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17208-13.

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$ 325.00
Cat# AO1410a
(40 western blots)
Availability: 7-10 days
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