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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   KLHL25 Antibody   

KLHL25 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - KLHL25 Antibody AO1418a
    Figure 1: Western blot analysis using KLHL25 mAb against KLHL25(AA: 2-230)-hIgGFc transfected HEK293 cell.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H0H3
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B7
Isotype IgG2b
Calculated MW 65kDa
Description KLHL25 (ectoderm-neural cortex protein 2, ENC2) is a cytoplasmic protein that contains six Kelch regions and a single BTB (POZ) domain. KLHL25 is highly homologus to another Kelch-like protein, ENC1, and it is believed to operate in a manner similar to other Kelch-domain containing proteins. Kelch-domain repeat containing proteins often act as modifiers of Actin fibers. Expressed early in embryogenesis, ENC1 helps to mediate neuronal process formation. It also appears to have a role in neural crest cell differentiation. KLHL25 likely functions as a substrate specific adapter for protein ubiquitinating complexes. KLHL25 is expressed in most tissues with highest expression in brain and liver.
Immunogen Purified recombinant fragment of human KLHL25 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 64410
Other Names Kelch-like protein 25, Ectoderm-neural cortex protein 2, ENC-2, KLHL25, ENC2
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLHL25 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL25
Synonyms ENC2
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Research Areas
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References

1. BMC Med Genet. 2007 Sep 19;8 Suppl 1:S13. 2. Genome Res. 2004 Oct;14(10B):2136-44.

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$ 325.00
Cat# AO1418a
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