|Application ||WB, FC, ICC, E|
|Description||Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.Tissue specificity: Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.|
|Immunogen||Purified recombinant fragment of human IL34 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide. |
|Other Names||Interleukin-34, IL-34, IL34, C16orf77|
|Dilution||WB~~1/500 - 1/2000|
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL34 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.|
|Tissue Location||Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.|
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Provided below are standard protocols that you may find useful for product applications.
1. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. 2. Lim J, et al. Cell, 2006 May 19. 3. Lin H, et al. Science, 2008 May 9.
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