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IL34 Antibody

Purified Mouse Monoclonal Antibody

     
  • WB - IL34 Antibody AO1424a
    Figure 1: Western blot analysis using IL34 mAb against IL34-hIgGFc transfected HEK293 cell lysate.
  • IF - IL34 Antibody AO1424a
    Figure 2: Immunofluorescence analysis of U251 cells using IL34 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • FC - IL34 Antibody AO1424a
    Figure 3: Flow cytometric analysis of K562 cells using IL34 mouse mAb (green) and negative control (purple).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, ICC, E
Primary Accession Q6ZMJ4
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1D12
Isotype IgG1
Calculated MW 27.5kDa
Description Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.Tissue specificity: Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
Immunogen Purified recombinant fragment of human IL34 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 146433
Other Names Interleukin-34, IL-34, IL34, C16orf77
Dilution WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL34 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL34
Synonyms C16orf77
Function Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Cellular Location Secreted.
Tissue Location Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
Research Areas
Citations (0)

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References

1. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. 2. Lim J, et al. Cell, 2006 May 19. 3. Lin H, et al. Science, 2008 May 9.

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$ 325.00
Cat# AO1424a
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