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ZBTB16 Antibody

Purified Mouse Monoclonal Antibody

  • WB - ZBTB16 Antibody AO1429a
    Figure 1: Western blot analysis using ZBTB16 mouse mAb against Hela (1) cell lysate.
  • IF - ZBTB16 Antibody AO1429a
    Figure 2: Immunofluorescence analysis of Hela cells using ZBTB16 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q05516
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5B3
Isotype IgG1
Calculated MW 74kDa
Description This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. Tissue specificity: Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
Immunogen Purified recombinant fragment of human ZBTB16 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 7704
Other Names Zinc finger and BTB domain-containing protein 16, Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF, ZBTB16, PLZF, ZNF145
Dilution WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZBTB16 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZBTB16
Synonyms PLZF, ZNF145
Function Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Cellular Location Nucleus.
Tissue Location Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung
Research Areas
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1. Cancer Res. 2008 Apr 15;68(8):2745-54 2. Immunity. 2008 Sep 19;29(3):391-403.

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$ 325.00
Cat# AO1429a
(40 western blots)
Availability: 7-10 days
Bulk Size
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